Epithelial cell morphogenesis

Across TCGA patient cohorts, RNA activity of the Epithelial cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF26, ISLR, and CNTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell morphogenesis activity versus ARHGEF26 in HNSC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGEF26 →	+1.042	+0.616	<.001	.002	3	5
CCRCC	ISLR →	+1.229	+0.595	.001	<.001	3	4
CCRCC	CNTN1 →	+0.967	+0.571	<.001	<.001	3	4
LSCC	DLX5 →	+1.069	+0.428	<.001	<.001	3	4
LSCC	KCTD15 →	+0.679	+0.348	<.001	.004	3	4
LSCC	GLI2 →	+0.917	+0.337	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003382 vs ARHGEF26 — HNSC

Explore this scatter interactively →