Brainstem development

Across TCGA patient cohorts, RNA activity of the Brainstem development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AOC3, SMAD4, and SYNC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Brainstem development activity versus AOC3 in OV (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AOC3 →	-0.582	-0.059	.002	.004	3	8
COAD	SMAD4 →	+0.273	+0.076	<.001	<.001	3	7
COAD	SYNC →	-0.743	-0.082	<.001	<.001	3	7
HNSC	ITGA7 →	-0.641	-0.118	<.001	<.001	3	7
HNSC	SYNM →	-0.933	-0.105	<.001	<.001	3	7
GBM	SYNPO2_T755 →	-0.712	-0.082	.002	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003360 vs AOC3 — OV

Explore this scatter interactively →