Positive regulation of cilium movement

Across TCGA cell cohorts, RNA activity of the Positive regulation of cilium movement pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR6, TACR2, and TACR3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCR6 grouped by Positive regulation of cilium movement-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR6 →	-0.291	-1.116	.003	.005	3	7
LIVER	TACR2 →	-0.228	-1.400	.005	<.001	3	7
CNS	TACR3 →	-0.306	-0.984	<.001	.005	2	7
BLOOD_Lymphoma	PGAM4 →	-0.496	-1.943	.001	<.001	3	6
LARGE_INTESTINE	TACR1 →	-0.210	-0.900	<.001	<.001	3	6
STOMACH	GRM4 →	-0.286	-1.106	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCR6 by Positive regulation of cilium movement activity — SOFT_TISSUE

Explore this box plot interactively →