Regulation of cilium movement

Across TCGA patient cohorts, RNA activity of the Regulation of cilium movement pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC40, LRTOMT, and CD3D, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium movement activity versus CCDC40 in UCEC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC40 →	+1.324	+0.088	<.001	<.001	3	23
UCEC	LRTOMT →	+0.920	+0.076	<.001	<.001	3	21
THYM	CD3D →	-2.013	-0.021	<.001	.001	3	21
UCEC	SPEF1 →	+2.342	+0.092	<.001	<.001	3	21
UCEC	RIBC1 →	+1.664	+0.090	<.001	<.001	3	21
UVM	CD2 →	-1.809	-0.030	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003352 vs CCDC40 — UCEC

Explore this scatter interactively →