Regulation of cilium movement

Across TCGA patient cohorts, RNA activity of the Regulation of cilium movement pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C7orf57_S209, TRAF3IP1, and TTC21B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium movement activity versus C7orf57_S209 in OV (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C7orf57_S209 →	+1.743	+0.106	<.001	<.001	3	8
BRCA	TRAF3IP1 →	+0.446	+0.040	<.001	<.001	3	7
BRCA	TTC21B →	+0.354	+0.052	<.001	<.001	3	7
UCEC	WDR19 →	+0.465	+0.130	<.001	<.001	3	7
UCEC	WDR35 →	+0.437	+0.118	<.001	<.001	3	7
UCEC	WDR54 →	+0.538	+0.120	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003352 vs C7orf57_S209 — OV

Explore this scatter interactively →