Regulation of cilium movement

Across TCGA cell cohorts, RNA activity of the Regulation of cilium movement pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2orf15, SHARPIN, and P3H1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium movement activity versus C2orf15 in BREAST (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C2orf15 →	-1.410	-0.386	.003	.003	3	4
OESOPHAGUS	SHARPIN →	-0.976	-0.481	.001	<.001	3	4
BREAST	P3H1 →	+1.585	+0.591	.001	<.001	3	3
BREAST	OPTN →	+2.091	+0.394	.004	.002	3	3
BREAST	THEM6 →	-1.289	-0.418	.003	.001	3	3
BREAST	NASP →	+1.159	+0.430	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003352 vs C2orf15 — BREAST

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