Cilium movement

Across TCGA patient cohorts, RNA activity of the Cilium movement pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CETN2, AK8, and PPIL6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cilium movement activity versus CETN2 in LUAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CETN2 →	+0.502	+0.478	<.001	.002	3	4
BRCA	AK8 →	+0.396	+0.319	.009	.001	2	5
BRCA	PPIL6 →	+0.569	+0.388	<.001	<.001	3	4
BRCA	CFAP57 →	+0.573	+0.500	.009	<.001	3	4
HNSC	ADAMTS7 →	-0.481	-0.743	.001	<.001	3	3
HNSC	DENND2B →	-0.352	-0.502	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003341 vs CETN2 — LUAD

Explore this scatter interactively →