Mesenchymal to epithelial transition involved in metanephros morphogenesis

Across TCGA cell cohorts, RNA activity of the Mesenchymal to epithelial transition involved in metanephros morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRCC, TNS2, and MPRIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRCC grouped by Mesenchymal to epithelial transition involved in metanephros morphogenesis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRCC →	-0.263	-1.681	.002	.001	3	4
BLOOD_Myeloma	TNS2 →	+0.256	+1.555	.007	.003	3	3
BLOOD_Myeloma	MPRIP →	+0.213	+1.420	<.001	<.001	3	3
BLOOD_Myeloma	PODN →	-0.323	-2.023	.005	<.001	3	3
BLOOD_Myeloma	ZNF445 →	-0.335	-1.908	<.001	<.001	3	3
LUNG_NSCLC_LUSC	KCNC3 →	+0.198	+1.559	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRCC by Mesenchymal to epithelial transition involved in metanephros morphogenesis activity — URINARY_TRACT

Explore this box plot interactively →