Amino acid transmembrane transport

Across TCGA patient cohorts, RNA activity of the Amino acid transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR8, TLR4, and SIRPB2, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid transmembrane transport activity versus TLR8 in LAML (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	TLR8 →	+3.009	+0.051	<.001	<.001	3	27
LAML	TLR4 →	+1.768	+0.039	<.001	<.001	3	27
LAML	SIRPB2 →	+1.133	+0.028	<.001	<.001	3	27
KIRC	CFLAR-AS1 →	+0.623	+0.032	<.001	<.001	3	27
ESCA	ADGRE2 →	+0.875	+0.040	<.001	<.001	3	27
THYM	PIK3CG →	+0.958	+0.030	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003333 vs TLR8 — LAML

Explore this scatter interactively →