Type B pancreatic cell differentiation

Across TCGA patient cohorts, RNA activity of the Type B pancreatic cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0CP3, ZNF561, and ZNF17, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type B pancreatic cell differentiation activity versus ATP6V0CP3 in CCRCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ATP6V0CP3 →	-0.348	-0.462	.001	.009	3	3
COAD	ZNF561 →	+0.509	+0.669	<.001	.004	3	3
BRCA	ZNF17 →	+0.369	+0.538	.009	.008	3	3
HNSC	C1orf159 →	-0.331	-0.203	.007	<.001	3	3
HNSC	PGS1 →	-0.418	-0.136	.003	.009	3	3
OV	DNAJC17 →	-0.242	-0.125	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003309 vs ATP6V0CP3 — CCRCC

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