Cardiac septum cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac septum cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNJ8, BMPR1A, and ITGA1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac septum cell differentiation activity versus KCNJ8 in CHOL (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	KCNJ8 →	+1.678	+0.113	<.001	<.001	3	29
THYM	BMPR1A →	+1.278	+0.098	<.001	<.001	3	28
SCLC	ITGA1 →	+1.236	+0.203	<.001	<.001	3	25
UVM	ATP8B2 →	+1.042	+0.043	<.001	<.001	3	25
SARC	DCHS1 →	+0.962	+0.075	<.001	<.001	3	25
DLBC	JMJD1C →	+1.344	+0.084	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003292 vs KCNJ8 — CHOL

Explore this scatter interactively →