Cardiac septum cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac septum cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL4A2, MMRN2, and NID2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac septum cell differentiation activity versus COL4A2 in COAD (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COL4A2 →	+0.427	+0.056	.002	.001	3	7
CCRCC	MMRN2 →	+0.582	+0.114	<.001	<.001	3	7
LSCC	NID2 →	+0.388	+0.087	<.001	<.001	3	7
CCRCC	PDE3A →	+0.595	+0.099	<.001	<.001	3	7
LUAD	PDE3A_S312 →	+0.644	+0.093	<.001	<.001	3	7
CCRCC	SHANK3_S375 →	+0.736	+0.092	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003292 vs COL4A2 — COAD

Explore this scatter interactively →