Septum primum development

Across TCGA patient cohorts, RNA activity of the Septum primum development pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSD2, CENPF, and CENPE, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Septum primum development activity versus NSD2 in THYM (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	NSD2 →	+1.120	+0.074	<.001	<.001	3	28
THYM	CENPF →	+1.683	+0.077	<.001	<.001	3	25
THYM	CENPE →	+1.396	+0.074	<.001	<.001	3	25
THYM	NCAPG →	+1.534	+0.065	<.001	<.001	3	24
THYM	CKAP2L →	+1.424	+0.072	<.001	<.001	3	24
MESO	IQGAP3 →	+1.206	+0.079	.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003284 vs NSD2 — THYM

Explore this scatter interactively →