Septum primum development

Across TCGA patient cohorts, RNA activity of the Septum primum development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB2, PLOD2, and CEP170, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Septum primum development activity versus TGFB2 in LSCC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TGFB2 →	+0.793	+0.102	<.001	<.001	3	7
PDAC	PLOD2 →	+0.687	+0.087	.001	<.001	3	6
HNSC	CEP170 →	+0.200	+0.081	<.001	.001	3	5
BRCA	MMP14 →	+0.378	+0.054	.001	<.001	2	6
OV	SLC9A3R1 →	-0.562	-0.083	<.001	<.001	3	5
OV	CCN1 →	+0.710	+0.097	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003284 vs TGFB2 — LSCC

Explore this scatter interactively →