Septum primum development

Across TCGA patient cohorts, RNA activity of the Septum primum development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN3, MYBL2, and E2F1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Septum primum development activity versus CDKN3 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDKN3 →	+1.029	+0.851	<.001	.001	3	6
BRCA	MYBL2 →	+1.410	+0.323	<.001	.002	3	6
GBM	E2F1 →	+1.033	+1.084	<.001	<.001	3	6
BRCA	NCAPD2 →	+0.675	+0.277	.001	.006	3	6
LSCC	RAD51AP1 →	+0.957	+0.814	<.001	.001	3	6
BRCA	CDCA3 →	+1.030	+0.350	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003284 vs CDKN3 — GBM

Explore this scatter interactively →