Septum primum development

Across TCGA cell cohorts, RNA activity of the Septum primum development pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFB2, GATA4, and NSD2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGFB2 grouped by Septum primum development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TGFB2 →	-0.376	-1.398	<.001	<.001	3	11
OVARY	GATA4 →	-0.211	-1.134	.001	<.001	3	8
CNS	NSD2 →	-0.241	-1.253	.002	<.001	3	7
SOFT_TISSUE	RNF182 →	-0.349	-1.107	<.001	.002	3	6
BLOOD_Lymphoma	ABTB2 →	-0.363	-1.445	<.001	.005	3	6
URINARY_TRACT	ACVR1 →	-0.170	-1.702	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGFB2 by Septum primum development activity — PANCREAS

Explore this box plot interactively →