Cardiac septum development

Across TCGA patient cohorts, RNA activity of the Cardiac septum development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AOC3, SLIT3, and ADAMTSL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac septum development activity versus AOC3 in UCEC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AOC3 →	+1.140	+0.360	.001	.002	3	7
LUAD	SLIT3 →	+0.871	+0.418	.001	.006	3	7
UCEC	ADAMTSL2 →	+1.607	+0.433	.005	<.001	3	6
BRCA	ITGA11 →	+1.014	+0.349	<.001	<.001	3	6
OV	JAM3 →	+0.689	+0.470	<.001	.004	3	6
HNSC	PRKD1 →	+0.653	+0.337	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003279 vs AOC3 — UCEC

Explore this scatter interactively →