Cardiac septum development

Across TCGA cell cohorts, RNA activity of the Cardiac septum development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF11A, BANF1, and DNAAF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac septum development activity versus TNFRSF11A in BLOOD_Lymphoma (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TNFRSF11A →	-2.136	-0.496	.002	.009	3	4
BREAST	BANF1 →	-0.549	-0.722	.004	.004	3	4
STOMACH	DNAAF1 →	-0.519	-1.374	<.001	<.001	3	4
OVARY	RILPL2 →	-0.648	-1.042	.002	.004	3	4
SKIN	CTXN1 →	-0.982	-0.749	.001	.007	3	4
BLOOD_Leukemia	ZEB2 →	-2.376	-0.744	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003279 vs TNFRSF11A — BLOOD_Lymphoma

Explore this scatter interactively →