Endocardial cushion fusion

Across TCGA patient cohorts, RNA activity of the Endocardial cushion fusion pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB2, DAP, and SEMA3C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion fusion activity versus TGFB2 in PDAC (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TGFB2 →	+0.963	+0.118	<.001	<.001	3	6
LSCC	DAP →	+0.229	+0.067	.002	<.001	3	5
PDAC	SEMA3C →	+0.353	+0.064	<.001	.001	3	4
LSCC	SERPINH1 →	+0.341	+0.061	.004	.001	3	4
LUAD	SPATS2L →	+0.413	+0.084	<.001	<.001	3	4
LUAD	CHAMP1_S452 →	-0.907	-0.109	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003274 vs TGFB2 — PDAC

Explore this scatter interactively →