Endocardial cushion fusion

Across TCGA pan-cancer cohorts, RNA activity of the Endocardial cushion fusion pathway is associated with patient survival in 15 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Endocardial cushion fusion pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and THYM, show the opposite pattern, with higher activity associated with better survival.

LGG, ACC, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.648	0.814	<.001	54	view →
ACC	DFS	Tertile	All	0.827	0.406	<.001	52	view →
READ	DFS	Quartile	III,IV	0.248	0.675	.013	26	view →
LAML	DFS	Tertile	All	0.301	0.566	.013	22	view →
CESC	OS	Tertile	All	0.706	0.832	.019	20	view →
THYM	DFS	Median	All	1.000	0.823	.003	20	view →
SKCM	DFS	Median	III,IV	0.166	0.399	.010	18	view →
SCLC	OS	Median	III,IV	0.564	0.282	.011	14	view →
KICH	OS	Tertile	III,IV	0.200	0.765	.019	12	view →
BRCA	OS	Quartile	All	0.987	0.952	.008	9	view →
GBM	DFS	Median	All	0.207	0.358	.019	6	view →
ESCA	DFS	Tertile	IV	0.242	0.704	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

GO:0003274–LGG (DFS)

Open the LGG breakdown →