Endocardial cushion fusion

Across TCGA patient cohorts, RNA activity of the Endocardial cushion fusion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN3, ZFPM2, and LCT-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion fusion activity versus CNN3 in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CNN3 →	+0.614	+0.263	.003	<.001	3	5
HNSC	ZFPM2 →	+0.856	+0.725	<.001	<.001	3	4
LUAD	LCT-AS1 →	+0.108	+0.422	<.001	.004	3	4
BRCA	ANKRD1 →	+0.887	+0.202	.003	.001	3	4
LSCC	UROD →	+0.225	+0.143	.001	.004	3	4
LSCC	NALCN →	+0.433	+0.318	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003274 vs CNN3 — LSCC

Explore this scatter interactively →