Endocardial cushion fusion

Across TCGA cell cohorts, RNA activity of the Endocardial cushion fusion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK14, SERTAD1, and FILIP1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPK14 grouped by Endocardial cushion fusion-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAPK14 →	-0.793	-1.379	.007	.005	2	5
BLOOD_Myeloma	SERTAD1 →	+0.762	+1.269	<.001	.003	3	4
LARGE_INTESTINE	FILIP1L →	-1.288	-0.703	<.001	.007	3	4
LARGE_INTESTINE	PIM3 →	+0.613	+1.112	<.001	<.001	3	4
LARGE_INTESTINE	P2RY11 →	+0.843	+0.758	.001	.003	3	4
OVARY	SEC11C →	+0.890	+0.911	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPK14 by Endocardial cushion fusion activity — STOMACH

Explore this box plot interactively →