Endocardial cushion fusion

Across TCGA cell cohorts, RNA activity of the Endocardial cushion fusion pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCCS, DNAAF5, and SELP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HCCS grouped by Endocardial cushion fusion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HCCS →	-0.312	-0.958	.001	<.001	3	4
BREAST	DNAAF5 →	-0.145	-0.843	.008	.006	3	4
LUNG_SCLC	SELP →	-0.221	-1.245	.007	.001	3	4
LUNG_SCLC	OR1D4 →	-0.199	-0.940	.002	.008	3	4
LUNG_NSCLC_LUAD	NFE2L1 →	-0.110	-0.167	.006	.001	3	4
KIDNEY	ABHD14B →	-0.321	-0.197	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HCCS by Endocardial cushion fusion activity — BREAST

Explore this box plot interactively →