Endocardial cushion formation

Across TCGA patient cohorts, RNA activity of the Endocardial cushion formation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL, BGN, and FMOD, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion formation activity versus VCL in CCRCC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VCL →	+0.479	+0.063	<.001	<.001	3	10
UCEC	BGN →	+1.053	+0.103	<.001	<.001	3	10
BRCA	FMOD →	+0.638	+0.047	<.001	<.001	3	10
OV	HSPG2 →	+0.580	+0.064	<.001	<.001	3	10
OV	NID2 →	+0.496	+0.059	<.001	<.001	3	10
UCEC	ARHGEF17 →	+0.464	+0.091	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003272 vs VCL — CCRCC

Explore this scatter interactively →