Endocardial cushion formation

Across TCGA patient cohorts, RNA activity of the Endocardial cushion formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX3, ZEB1, and GOLIM4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion formation activity versus TBX3 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBX3 →	+1.457	+0.463	<.001	<.001	3	6
CCRCC	ZEB1 →	+0.609	+0.938	<.001	.001	3	6
UCEC	GOLIM4 →	+1.000	+0.686	<.001	.005	3	5
UCEC	FOXS1 →	+0.800	+0.877	.002	<.001	2	6
CCRCC	TBX2-AS1 →	+0.918	+0.827	<.001	<.001	3	5
CCRCC	ZNF423 →	+0.566	+1.109	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003272 vs TBX3 — BRCA

Explore this scatter interactively →