Endocardial cushion formation

Across TCGA cell cohorts, RNA activity of the Endocardial cushion formation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTRC, LENG8, and ZNF580, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BTRC grouped by Endocardial cushion formation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BTRC →	+0.761	+1.033	.005	.008	3	4
SOFT_TISSUE	LENG8 →	-1.525	-1.353	<.001	.001	3	4
SOFT_TISSUE	ZNF580 →	-1.065	-1.579	.004	<.001	3	4
BLOOD_Myeloma	ATP13A1 →	-0.727	-1.466	.007	.001	3	4
LUNG_NSCLC_LUAD	THBS3 →	-0.946	-0.757	.003	.001	2	5
CNS	GPAA1 →	-0.653	-0.767	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BTRC by Endocardial cushion formation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →