Cardiac neural crest cell migration involved in outflow tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac neural crest cell migration involved in outflow tract morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAI14, TNS1, and ILK, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac neural crest cell migration involved in outflow tract morphogenesis activity versus RAI14 in HNSC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RAI14 →	+0.341	+0.071	<.001	.003	3	10
BRCA	TNS1 →	+0.500	+0.078	.001	<.001	3	9
BRCA	ILK →	+0.446	+0.067	<.001	.001	3	9
BRCA	PARVA →	+0.526	+0.077	<.001	<.001	3	9
CCRCC	PRKG1 →	+0.593	+0.099	<.001	<.001	3	9
LSCC	TIMP3 →	+0.909	+0.130	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003253 vs RAI14 — HNSC

Explore this scatter interactively →