Cardiac neural crest cell migration involved in outflow tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac neural crest cell migration involved in outflow tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSM5, RN7SKP70, and JHY, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac neural crest cell migration involved in outflow tract morphogenesis activity versus ACSM5 in CCRCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ACSM5 →	+1.014	+0.169	.003	.005	3	4
BRCA	RN7SKP70 →	+0.726	+0.310	.001	.003	3	4
COAD	JHY →	+0.547	+0.149	<.001	.001	3	4
BRCA	KCTD10 →	+0.394	+0.285	<.001	.001	3	4
LSCC	TSHZ3 →	+0.783	+0.581	<.001	.001	3	4
BRCA	RBMS3 →	+0.609	+0.316	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003253 vs ACSM5 — CCRCC

Explore this scatter interactively →