Growth involved in heart morphogenesis

Across TCGA patient cohorts, RNA activity of the Growth involved in heart morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRAP, TNS2_S941, and IGF2BP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth involved in heart morphogenesis activity versus GRAP in CCRCC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GRAP →	+0.453	+0.118	<.001	<.001	3	5
LSCC	TNS2_S941 →	+0.506	+0.112	<.001	<.001	3	5
LUAD	IGF2BP3 →	-1.194	-0.073	.004	.001	3	5
HNSC	SNTA1 →	+0.908	+0.109	<.001	<.001	3	5
LSCC	ATXN2L →	-0.185	-0.106	.001	<.001	3	5
LSCC	TNS2_S102 →	+0.414	+0.081	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003241 vs GRAP — CCRCC

Explore this scatter interactively →