Growth involved in heart morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Growth involved in heart morphogenesis pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 4 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Growth involved in heart morphogenesis pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and THCA, show the opposite pattern, with higher activity associated with better survival.

KIRP, BRCA, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	IV	0.037	0.595	.001	55	view →
BRCA	DFS	Median	II,III,IV	0.918	0.962	.002	44	view →
KIRC	DFS	Median	All	0.758	0.501	<.001	34	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
THCA	OS	Tertile	II,III,IV	1.000	0.923	.007	23	view →
OV	OS	Quartile	IV	0.241	0.636	.003	18	view →
LGG	DFS	Tertile	All	0.867	0.764	.003	16	view →
PAAD	DFS	Median	All	0.389	0.153	.002	15	view →
COAD	DFS	Quartile	IV	0.224	0.604	.023	11	view →
DLBC	DFS	Median	All	0.691	0.939	.018	10	view →
LUSC	OS	Median	All	0.619	0.721	.006	10	view →
ACC	OS	Median	II,III,IV	0.448	0.843	.019	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0003241–KIRP (DFS)

Open the KIRP breakdown →