Growth involved in heart morphogenesis

Across TCGA patient cohorts, RNA activity of the Growth involved in heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01507, POM121L9P, and COX11P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth involved in heart morphogenesis activity versus LINC01507 in PDAC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LINC01507 →	+0.657	+0.162	<.001	.008	3	4
UCEC	POM121L9P →	-0.344	-0.327	.005	.006	3	3
LSCC	COX11P1 →	+0.120	+0.226	.004	.003	3	3
PDAC	ZBTB46 →	+0.528	+0.186	<.001	.002	3	3
PDAC	RPSAP70 →	+0.415	+0.140	.007	.005	3	3
CCRCC	FCF1P8 →	+0.754	+0.279	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003241 vs LINC01507 — PDAC

Explore this scatter interactively →