Growth involved in heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Growth involved in heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM31, UBE2I, and UCK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM31 grouped by Growth involved in heart morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMEM31 →	-0.158	-0.768	.004	.006	3	4
BLOOD_Leukemia	UBE2I →	+0.646	+1.242	.003	.002	2	5
BREAST	UCK1 →	+0.496	+0.783	.008	<.001	3	4
BREAST	JMJD8 →	+0.638	+0.716	.002	.002	3	4
SOFT_TISSUE	KHDRBS3 →	+3.489	+1.575	<.001	<.001	3	4
BONE	TNFAIP3 →	-1.363	-1.530	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM31 by Growth involved in heart morphogenesis activity — STOMACH

Explore this box plot interactively →