Cardiac atrium development

Across TCGA patient cohorts, RNA activity of the Cardiac atrium development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK1, CLEC11A, and HMCN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac atrium development activity versus DOCK1 in UCEC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOCK1 →	+0.380	+0.064	<.001	.001	3	9
BRCA	CLEC11A →	+0.721	+0.039	<.001	<.001	3	8
BRCA	HMCN1 →	+0.706	+0.052	<.001	<.001	3	8
CCRCC	MPRIP →	+0.290	+0.058	<.001	<.001	3	8
BRCA	TLN2 →	+0.632	+0.056	<.001	<.001	3	8
BRCA	ANGPTL2 →	+0.642	+0.042	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003230 vs DOCK1 — UCEC

Explore this scatter interactively →