Cardiac atrium development

Across TCGA patient cohorts, RNA activity of the Cardiac atrium development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK2, DCLK2, and CHRDL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac atrium development activity versus ANK2 in CCRCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANK2 →	+1.226	+0.516	<.001	<.001	3	7
BRCA	DCLK2 →	+0.855	+0.382	<.001	<.001	3	6
UCEC	CHRDL1 →	+1.149	+0.355	.004	.001	3	6
OV	SLIT3 →	+0.897	+0.159	.004	.008	3	6
OV	AKT3 →	+0.989	+0.181	.001	.001	3	6
GBM	PDE1B →	+0.579	+0.781	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003230 vs ANK2 — CCRCC

Explore this scatter interactively →