Cardiac atrium development

Across TCGA cell cohorts, RNA activity of the Cardiac atrium development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNGA4, SUPT6H, and MOCOS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNGA4 grouped by Cardiac atrium development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CNGA4 →	-0.283	-0.066	.001	<.001	3	5
BONE	SUPT6H →	-0.286	-0.050	.007	.008	3	4
LUNG_NSCLC_LUSC	MOCOS →	+0.287	+0.065	.009	.006	3	4
BLOOD_Myeloma	PIWIL2 →	+0.306	+0.047	.003	.004	3	4
BLOOD_Lymphoma	AADAT →	+0.505	+0.062	<.001	.001	3	3
SOFT_TISSUE	USP21 →	-0.210	-0.124	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNGA4 by Cardiac atrium development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →