Cardiac atrium development

Across TCGA cell cohorts, RNA activity of the Cardiac atrium development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH9, ARHGEF40, and PIK3R2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac atrium development activity versus MYH9 in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYH9 →	+0.789	+0.062	<.001	<.001	3	7
STOMACH	ARHGEF40 →	+1.559	+0.050	<.001	.005	3	7
CNS	PIK3R2 →	+0.987	+0.059	.001	.003	3	6
SKIN	VGLL4 →	+0.750	+0.046	.001	.003	3	6
SKIN	NOTCH1 →	+1.402	+0.086	<.001	<.001	3	6
SKIN	FLCN →	+0.959	+0.047	<.001	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003230 vs MYH9 — BLOOD_Leukemia

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