Cardiac atrium development

Across TCGA cell cohorts, RNA activity of the Cardiac atrium development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPCL2, TEPP, and FNDC5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac atrium development activity versus HNRNPCL2 in LUNG_NSCLC_LUAD (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HNRNPCL2 →	+0.093	+1.506	.002	.002	3	3
SKIN	TEPP →	+0.063	+1.076	.005	<.001	3	3
CNS	FNDC5 →	+0.690	+0.714	.003	.007	3	3
CNS	COX18 →	-0.707	-0.929	.002	.002	3	3
OVARY	CD63 →	+1.221	+0.499	<.001	<.001	3	3
OVARY	KRTAP2-3 →	+2.404	+0.284	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003230 vs HNRNPCL2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →