Ventricular compact myocardium morphogenesis

Across TCGA patient cohorts, RNA activity of the Ventricular compact myocardium morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFBR3, P4HB, and ERO1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular compact myocardium morphogenesis activity versus TGFBR3 in BRCA (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TGFBR3 →	+0.517	+0.073	<.001	<.001	3	6
UCEC	P4HB →	-0.286	-0.069	.002	.003	3	6
PDAC	ERO1A →	-0.489	-0.070	<.001	<.001	3	5
LUAD	TALDO1_S237 →	+0.380	+0.058	.002	<.001	3	5
PDAC	TATDN3 →	+0.222	+0.086	.001	<.001	3	5
LUAD	DPYD_S905 →	-0.567	-0.083	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003223 vs TGFBR3 — BRCA

Explore this scatter interactively →