Ventricular compact myocardium morphogenesis

Across TCGA patient cohorts, RNA activity of the Ventricular compact myocardium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSP, ZEB2, and FLI1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular compact myocardium morphogenesis activity versus DSP in CCRCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DSP →	+1.410	+0.842	<.001	<.001	3	7
HNSC	ZEB2 →	-0.677	-1.078	<.001	.001	3	7
BRCA	FLI1 →	-0.695	-0.942	<.001	<.001	3	6
HNSC	LGI2 →	-0.786	-1.042	.007	.004	3	6
BRCA	CD37 →	-0.738	-0.759	.001	<.001	3	6
HNSC	WIPF1 →	-0.732	-0.954	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003223 vs DSP — CCRCC

Explore this scatter interactively →