Ventricular compact myocardium morphogenesis

Across TCGA cell cohorts, RNA activity of the Ventricular compact myocardium morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD7, BMPR1A, and NOG, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHD7 grouped by Ventricular compact myocardium morphogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CHD7 →	-0.426	-1.230	<.001	<.001	3	11
LARGE_INTESTINE	BMPR1A →	-0.261	-1.192	.003	.003	3	9
CNS	NOG →	-0.231	-0.761	.001	.002	2	6
KIDNEY	LRP2 →	-0.308	-1.436	<.001	<.001	3	5
BLOOD_Myeloma	ASCL1 →	+0.308	+1.581	.004	<.001	3	4
LUNG_NSCLC_LUAD	DSP →	-0.323	-1.256	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHD7 by Ventricular compact myocardium morphogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →