Ventricular compact myocardium morphogenesis

Across TCGA cell cohorts, RNA activity of the Ventricular compact myocardium morphogenesis pathway is significantly associated with the total protein of multiple features, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are FOXO3a, ADAR1, and 14-3-3_beta, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular compact myocardium morphogenesis activity versus FOXO3a in BREAST (Pearson r = 0.92).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FOXO3a →	+0.406	+0.222	.009	.013	2	1
BREAST	ADAR1 →	+0.884	+0.222	.006	.013	2	1
BREAST	14-3-3_beta →	-0.461	-0.238	.007	.038	1	1
BREAST	GAPDH →	+1.178	+0.222	.024	.013	1	1
BREAST	PDCD4 →	+2.879	+0.222	.040	.013	1	1
BREAST	Bim(CST2933) →	-2.428	-0.238	.003	.038	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003223 vs FOXO3a — BREAST

Explore this scatter interactively →