Ventricular compact myocardium morphogenesis

Across TCGA cell cohorts, RNA activity of the Ventricular compact myocardium morphogenesis pathway is significantly associated with the drug response of multiple features, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are EHT-1864, PHA-793887, and SNX-2112, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EHT-1864 grouped by Ventricular compact myocardium morphogenesis-low versus -high activity in BREAST.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EHT-1864 →	+0.443	+0.222	.027	.013	2	1
BREAST	PHA-793887 →	-1.069	-0.238	.015	.038	2	1
BREAST	SNX-2112 →	-1.089	-0.238	.015	.038	2	1
BREAST	RU-SKI 43 →	-0.929	-0.238	.027	.038	2	1
BREAST	Genentech Cpd 10 →	-0.730	-0.238	.044	.038	1	1
BREAST	QL-X-138 →	-1.344	-0.238	.041	.038	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EHT-1864 by Ventricular compact myocardium morphogenesis activity — BREAST

Explore this box plot interactively →