Ventricular trabecula myocardium morphogenesis

Across TCGA patient cohorts, RNA activity of the Ventricular trabecula myocardium morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SULF1, PCOLCE, and POSTN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular trabecula myocardium morphogenesis activity versus SULF1 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SULF1 →	+0.724	+0.057	<.001	.001	3	8
CCRCC	PCOLCE →	+0.877	+0.068	<.001	<.001	3	7
UCEC	POSTN →	+0.753	+0.079	.002	.002	3	7
LUAD	VCAN_S1349 →	+0.998	+0.080	<.001	<.001	3	7
UCEC	LAMA4 →	+0.548	+0.092	.001	.002	2	8
CCRCC	LAMB1 →	+0.506	+0.081	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003222 vs SULF1 — LSCC

Explore this scatter interactively →