Ventricular trabecula myocardium morphogenesis

Across TCGA patient cohorts, RNA activity of the Ventricular trabecula myocardium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BUB1B, PARPBP, and CDC6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular trabecula myocardium morphogenesis activity versus BUB1B in UCEC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB1B →	+0.869	+0.351	<.001	<.001	3	4
UCEC	PARPBP →	+0.616	+0.279	.008	.001	3	4
UCEC	CDC6 →	+0.809	+0.327	.001	<.001	3	4
LUAD	STEAP2 →	-0.638	-0.509	<.001	.001	3	3
LUAD	ZNF37BP →	+0.464	+0.830	<.001	<.001	3	3
UCEC	FAM83D →	+0.645	+0.297	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003222 vs BUB1B — UCEC

Explore this scatter interactively →