Ventricular trabecula myocardium morphogenesis

Across TCGA cell cohorts, RNA activity of the Ventricular trabecula myocardium morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLG, CCT2, and RELB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLG grouped by Ventricular trabecula myocardium morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	POLG →	-0.266	-0.212	.008	.006	3	5
LIVER	CCT2 →	+0.534	+0.250	<.001	.002	3	5
SOFT_TISSUE	RELB →	+0.315	+0.133	<.001	.004	3	4
BREAST	DNAJB6 →	+0.224	+0.162	<.001	<.001	3	4
URINARY_TRACT	NSD2 →	-0.123	-0.188	.008	.001	3	4
BLOOD_Myeloma	CSMD1 →	-0.382	-0.074	.004	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLG by Ventricular trabecula myocardium morphogenesis activity — LIVER

Explore this box plot interactively →