Ventricular trabecula myocardium morphogenesis

Across TCGA cell cohorts, RNA activity of the Ventricular trabecula myocardium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETNK2, ICAM5, and VCP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular trabecula myocardium morphogenesis activity versus ETNK2 in STOMACH (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ETNK2 →	-2.889	-0.412	<.001	.002	3	4
BLOOD_Lymphoma	ICAM5 →	-2.235	-0.366	<.001	.009	3	4
OESOPHAGUS	VCP →	-0.971	-0.371	.001	.009	3	3
OESOPHAGUS	CHRNB1 →	-1.972	-0.378	.005	.008	3	3
OESOPHAGUS	DTX3 →	-2.411	-0.288	<.001	.008	3	3
CNS	STK24 →	+0.605	+0.591	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003222 vs ETNK2 — STOMACH

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