Cardiac left ventricle morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac left ventricle morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDNRA, ADGRA2, and ADCY4, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac left ventricle morphogenesis activity versus EDNRA in THYM (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	EDNRA →	+2.514	+0.112	<.001	<.001	3	29
TGCT	ADGRA2 →	+2.040	+0.099	<.001	<.001	3	27
KIRC	ADCY4 →	+1.129	+0.087	<.001	<.001	3	27
STAD	CALHM5 →	+0.838	+0.096	<.001	<.001	3	27
TGCT	NID1 →	+2.301	+0.123	<.001	<.001	3	26
THYM	CCN2 →	+3.447	+0.105	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003214 vs EDNRA — THYM

Explore this scatter interactively →