Cardiac ventricle formation

Across TCGA patient cohorts, RNA activity of the Cardiac ventricle formation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM2, MCM4, and MCM6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac ventricle formation activity versus MCM2 in LSCC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM2 →	-0.445	-0.105	.009	<.001	3	8
UCEC	MCM4 →	-0.535	-0.108	<.001	<.001	3	8
UCEC	MCM6 →	-0.597	-0.109	.001	.001	3	8
LUAD	DDX18 →	-0.279	-0.072	<.001	<.001	3	7
UCEC	MCM7 →	-0.578	-0.116	<.001	<.001	3	7
LUAD	KIF15_S568 →	-0.849	-0.082	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003211 vs MCM2 — LSCC

Explore this scatter interactively →