Cardiac atrium morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac atrium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADTRP, SWAP70, and HOXA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADTRP grouped by Cardiac atrium morphogenesis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ADTRP →	-1.098	-1.276	.002	.004	3	5
STOMACH	SWAP70 →	-1.668	-1.115	.008	.001	3	4
BONE	HOXA3 →	-1.120	-1.109	.008	.003	3	4
BONE	CRIM1 →	-3.454	-1.285	.008	.008	2	5
BONE	TRIM11 →	+0.684	+1.294	.001	.005	3	4
PANCREAS	DNAI4 →	-0.976	-0.645	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADTRP by Cardiac atrium morphogenesis activity — BONE

Explore this box plot interactively →