Cardiac chamber formation

Across TCGA patient cohorts, RNA activity of the Cardiac chamber formation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, SPARCL1_S295, and NID1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac chamber formation activity versus RSU1 in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RSU1 →	+0.521	+0.078	.002	.002	3	8
CCRCC	SPARCL1_S295 →	+0.917	+0.109	<.001	<.001	3	8
BRCA	NID1 →	+0.305	+0.035	<.001	<.001	3	8
LUAD	ITIH5 →	+0.374	+0.075	.001	.001	3	8
UCEC	ITGA1 →	+0.932	+0.100	<.001	<.001	3	7
OV	OLFML3 →	+0.749	+0.074	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003207 vs RSU1 — UCEC

Explore this scatter interactively →